| Pair Name | Curcumol, Cisplatin | ||
| Phytochemical Name | Curcumol (PubChem CID: 14240392 ) | ||
| Anticancer drug Name | Cisplatin (PubChem CID: 5702198 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Curcumol, Cisplatin | |||
| Disease Info | [ICD-11: 2B72.Z] | Gastric cancer | Investigative | |
| Gene Regulation | Up-regulation | Expression | MIR7 | hsa10859 |
| Down-regulation | Expression | NFKB1 | hsa4790 | |
| Down-regulation | Expression | RELA | hsa5970 | |
| Down-regulation | Expression | SNAI1 | hsa6615 | |
| In Vitro Model | AGS | Gastric adenocarcinoma | Homo sapiens (Human) | CVCL_0139 |
| MKN45 | Gastric adenocarcinoma | Homo sapiens (Human) | CVCL_0434 | |
| HGC-27 | Gastric carcinoma | Homo sapiens (Human) | CVCL_1279 | |
| NCI-N87 | Gastric tubular adenocarcinoma | Homo sapiens (Human) | CVCL_1603 | |
| Result | The findings may offer new thoughts that curcumol in combination with cisplatin might be a useful strategy for GC management. | |||
| Pair Name | Curcumol, Cisplatin | |||
| Disease Info | [ICD-11: 2B51] | Osteosarcoma | Investigative | |
| Biological Phenomena | Inhibition-->Cell metastasis | |||
| Gene Regulation | Down-regulation | Expression | ABCB1 | hsa5243 |
| Down-regulation | Expression | ABCC1 | hsa4363 | |
| Down-regulation | Expression | ABCG2 | hsa9429 | |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Up-regulation | Cleavage | PARP1 | hsa142 | |
| In Vitro Model | K7M2-WT | Osteosarcoma | Mus musculus (Mouse) | CVCL_V455 |
| U2OS | Osteosarcoma | Homo sapiens (Human) | CVCL_0042 | |
| MG-63 | Osteosarcoma | Homo sapiens (Human) | CVCL_0426 | |
| KH OS R1 | Osteosarcoma | Homo sapiens (Human) | CVCL_T431 | |
| Result | These findings suggest that curcumol inhibits the polarization of M2-like macrophages and could be a promising combination strategy to synergize with CDDP in the osteosarcoma. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Curcumol enhances cisplatin sensitivity of gastric cancer: involvement of microRNA-7 and the nuclear factor-kappa B/snail family transcriptional repressor 1 axis. Bioengineered. 2022 May;13(5):11668-11683. doi: 10.1080/21655979.2022.2070975. | Click |
| 2 | Curcumol Synergizes with Cisplatin in Osteosarcoma by Inhibiting M2-like Polarization of Tumor-Associated Macrophages. Molecules. 2022 Jul 6;27(14):4345. doi: 10.3390/molecules27144345. | Click |
